Description

5-Pyrimidinecarboxamide, 2-Amino-n-(1-Ethyl-3-Pyrrolidinyl)-4-Methoxy- , (E)-2-Butenedioate (1:1) is a high-purity, non-racemic pharmaceutical intermediate with a specific stereochemical configuration. This compound is of significant commercial interest due to its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily required by pharmaceutical research and development organizations and contract manufacturing organizations (CMOs) engaged in the production of advanced therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel drug candidates, particularly in central nervous system (CNS) and antiviral therapeutic areas.
• Active Pharmaceutical Ingredient (API) Development: Serves as a chiral building block for constructing complex molecular architectures with defined biological activity.
• Process Chemistry & Scale-Up: Used in route scouting, optimization, and cGMP manufacturing campaigns for clinical trial material and commercial API supply.
• Biochemical Research: Employed in academic and industrial laboratories for studying enzyme inhibition, receptor binding, and structure-activity relationships (SAR).
• Reference Standard: Provides a high-purity standard for analytical method development, validation, and quality control testing of final drug substances.

Basic Information

Product Name	5-Pyrimidinecarboxamide, 2-Amino-n-(1-Ethyl-3-Pyrrolidinyl)-4-Methoxy- , (E)-2-Butenedioate (1:1)
CAS No.	84332-17-2
Molecular Formula	C16H25N5O6
Molecular Weight	383.40 g/mol
Synonyms	2-Amino-N-[(3R)-1-ethylpyrrolidin-3-yl]-4-methoxypyrimidine-5-carboxamide fumarate; (R)-2-Amino-N-(1-ethyl-3-pyrrolidinyl)-4-methoxy-5-pyrimidinecarboxamide (E)-2-butenedioate; Fumarate salt of a pyrimidinecarboxamide derivative; UNII-9Q2I6S6A1F; Adefovir dipivoxil intermediate (related compound); (R)-Adefovir intermediate fumarate; Pyrrolidine-pyrimidine fumarate salt.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and traceability. Quality is verified through a comprehensive suite of analytical techniques including HPLC, chiral HPLC, NMR, and mass spectrometry to confirm identity, purity, and enantiomeric excess. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with agreed specifications. We support development and commercial projects requiring GMP-grade materials and relevant regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccants or a nitrogen atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single unknown impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.