Description

n-Boc-α-Methyl-L-Serine is a high-purity, protected amino acid derivative essential for advanced peptide synthesis. This compound is a critical building block for medicinal chemists, enabling the precise introduction of a serine residue with an α-methyl modification, which can enhance metabolic stability and conformational rigidity in target peptides. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of novel therapeutic agents, peptide-based drugs, and complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate a sterically hindered, protected serine analogue.
• Protease Inhibitor Development: Serves as a crucial component in the design and synthesis of selective protease inhibitors.
• Conformationally Constrained Peptide Mimetics: Enables the creation of peptidomimetics with enhanced stability and bioavailability for drug discovery programs.
• Biochemical Research: Employed in academic and industrial research to study enzyme-substrate interactions and protein structure-function relationships.
• Custom Synthesis Services: A fundamental starting material for contract research and manufacturing organizations (CROs/CMOs) offering bespoke chemical synthesis.

Basic Information

Product Name	n-Boc-α-Methyl-L-Serine
CAS No.	84311-19-3
Molecular Formula	C9H17NO5
Molecular Weight	219.24 g/mol
Synonyms	(2S)-2-[(tert-Butoxycarbonyl)amino]-2-methyl-3-hydroxypropanoic Acid; Boc-α-Me-L-Ser-OH; N-(tert-Butoxycarbonyl)-α-methyl-L-serine; tert-Butyl (1S)-1-carboxy-2-hydroxy-1-methylethylcarbamate; Boc-α-Methylserine; α-Methyl-N-Boc-L-serine; (S)-2-((tert-Butoxycarbonyl)amino)-2-methyl-3-hydroxypropanoic Acid
EINECS	Contact for details

Quality Control

Our n-Boc-α-Methyl-L-Serine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality protocols are designed to meet the stringent requirements of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.