Description

4'-α-D-Glucopyranosylkanamycin B is a semi-synthetic aminoglycoside antibiotic derivative, primarily valued for its research and development applications in combating resistant bacterial strains. Its significance lies in its modified structure, which is studied to understand and potentially overcome common mechanisms of aminoglycoside resistance. This compound is essential for pharmaceutical R&D laboratories, academic institutions, and biotechnology companies focused on antimicrobial discovery and mechanism of action studies. A Certificate of Analysis is provided to ensure batch-to-batch consistency and support critical research outcomes.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or reference standard in the synthesis and study of novel aminoglycoside antibiotics.
• Antimicrobial Mechanism Studies: Used in biochemical and microbiological assays to investigate bacterial resistance patterns and drug-target interactions.
• Analytical Reference Standard: Employed as a high-purity calibrant in HPLC, LC-MS, and other analytical methods for quality control of related pharmaceutical compounds.
• Biochemical Tool Compound: Applied in enzymatic studies and molecular biology research to probe ribosomal function and protein synthesis inhibition.
• Preclinical Development: Evaluated in in vitro and in vivo models for its pharmacokinetic and pharmacodynamic properties.

Basic Information

Product Name	4'-α-D-Glucopyranosylkanamycin B
CAS No.	84123-75-1
Molecular Formula	C26H50N6O16
Molecular Weight	678.71 g/mol
Synonyms	4'-α-D-Glucopyranosylkanamycin B; Kanamycin B 4'-α-D-glucopyranoside; 6'''-Amino-6'''-deoxy-α-D-glucopyranosylkanamycin B; Antibiotic NK 1003; NK-1003; Glucokanamycin B; 4'-α-Glucosylkanamycin B; 1-N-[(S)-4-Amino-2-hydroxybutyryl]-4'-α-D-glucopyranosylkanamycin B derivative
EINECS	Contact for details

Quality Control

Every batch of 4'-α-D-Glucopyranosylkanamycin B is manufactured and tested under a strict quality management system. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with high-purity standards for research use. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and potency. For long-term storage, consider storing under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm
Bacterial Endotoxins	< 1.0 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.