Description

Fmoc-His(Bzl)-Oh CAS NO 84030-19-3 is a protected derivative of the amino acid histidine, specifically designed for solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring precise control over peptide chain assembly, particularly when incorporating the histidine residue. It is an essential building block for the pharmaceutical, biotechnology, and life sciences industries, enabling the development of therapeutic peptides, diagnostic agents, and biochemical research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated, stepwise construction of complex peptide sequences.
• Pharmaceutical Research & Development: Used in the synthesis of peptide-based drug candidates, including hormones, enzyme inhibitors, and antimicrobial peptides.
• Bioconjugation and Probe Development: Serves as a precursor for creating labeled peptides or peptide-protein conjugates for diagnostic and imaging applications.
• Combinatorial Chemistry Libraries: A fundamental component in generating diverse peptide libraries for high-throughput screening against biological targets.
• Academic and Industrial Research: Employed in biochemical studies to investigate protein-protein interactions, enzyme mechanisms, and structure-activity relationships (SAR).

Basic Information

Product Name	Fmoc-His(Bzl)-Oh
CAS No.	84030-19-3
Molecular Formula	C28H26N4O5
Molecular Weight	498.53 g/mol
Synonyms	Fmoc-His(Bzl)-OH; N-α-Fmoc-N-π-benzyl-L-histidine; Fmoc-L-histidine(N-π-benzyl)-OH; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonylamino)-3-(1-benzyl-1H-imidazol-4-yl)propanoic acid; Fmoc-His(Bzl); FMOC-HIS(BZL)-OH; Fmoc-His(Bzl)-OH, Fmoc protected amino acid; Fmoc-Histidine(Bzl)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-His(Bzl)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive peptide synthesis applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to industry best practices, and specifications can be tailored to meet specific research or cGMP requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Optical Rotation [α]	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.