Description

n-Fmoc-n-Methyl-o-Benzyl-L-Serine CAS NO 84000-14-6 is a protected, non-proteinogenic amino acid derivative of significant importance in modern synthetic organic and medicinal chemistry. Its core value lies in providing a versatile, orthogonally protected serine building block, enabling the precise synthesis of complex peptides and peptidomimetics. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those developing novel therapeutic peptides, glycopeptides, and constrained peptide libraries where side-chain modification and controlled stereochemistry are critical.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc-strategy, facilitating the controlled incorporation of O-benzyl serine with an N-methylated backbone.
• Peptidomimetic Drug Discovery: Used to synthesize peptide analogs with enhanced metabolic stability, bioavailability, and receptor selectivity by introducing N-methylation.
• Glycopeptide Synthesis: Serves as a precursor for introducing serine-linked carbohydrate moieties in the development of synthetic vaccines and glycoprotein mimics.
• Combinatorial Chemistry Libraries: Employed in generating diverse arrays of modified peptides for high-throughput screening against biological targets.
• Conformationally Constrained Peptides: The N-methyl and O-benzyl groups introduce steric and conformational constraints, aiding in the study of structure-activity relationships (SAR).
• Intermediate for Fine Chemicals: Acts as a chiral synthon in the asymmetric synthesis of more complex, non-peptide bioactive molecules.

Basic Information

Product Name	n-Fmoc-n-Methyl-o-Benzyl-L-Serine
CAS No.	84000-14-6
Molecular Formula	C26H25NO5
Molecular Weight	431.48 g/mol
Synonyms	Fmoc-N-Me-Ser(Bzl)-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl(methyl)amino]-3-(phenylmethoxy)propanoic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-O-benzyl-L-serine; Fmoc-N-methyl-O-benzyl-L-serine; N-Fmoc-N-methyl-O-benzyl-L-serine; N-α-Fmoc-N-α-methyl-O-benzyl-L-serine; L-Serine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-, phenylmethyl ester (related ester form); Fmoc-Ser(Bzl, N-Me)-OH
EINECS	Contact for details

Quality Control

Our n-Fmoc-n-Methyl-o-Benzyl-L-Serine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for demanding research and cGMP intermediate applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements, including custom purity grades.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥97.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.