Description

H-Pro-His-Val-Oh CAS NO 83960-33-2 is a high-purity tripeptide derivative, specifically the C-terminal carboxylic acid form of the sequence Proline-Histidine-Valine. This compound serves as a critical building block and reference standard in advanced pharmaceutical research and peptide synthesis. It is essential for researchers and manufacturers developing novel therapeutic peptides, diagnostic agents, and biochemical tools. The product's defined structure ensures reproducibility and reliability in complex synthetic pathways and analytical applications.

Application

• Pharmaceutical Intermediate: A key raw material in the synthesis of longer, biologically active peptide chains for drug discovery and development.
• Biochemical Research: Used as a reference standard in analytical methods like HPLC and mass spectrometry for peptide identification and quantification.
• Peptide Library Construction: A fundamental component in solid-phase and solution-phase peptide synthesis for creating diverse compound libraries.
• Enzyme Substrate/Analogue: Potential use in studying enzyme kinetics and inhibition, particularly for proteases and other enzymes interacting with proline/histidine-rich sequences.
• Cosmetic Peptide Synthesis: A precursor for synthesizing specialized peptides used in advanced skincare and cosmetic formulations.

Basic Information

Product Name	H-Pro-His-Val-Oh
CAS No.	83960-33-2
Molecular Formula	C16H25N5O5
Molecular Weight	367.40 g/mol
Synonyms	L-Prolyl-L-histidyl-L-valine; Pro-His-Val-OH; H-Pro-His-Val-OH; PHV; L-Pro-L-His-L-Val; Proline-Histidine-Valine; N-[(2S)-1-[[(2S)-1-[(2S)-2-Pyrrolidinylcarbonyl]-2-imidazol-4-ylethyl]amino]-3-methyl-1-oxobutan-2-yl]carbamic Acid
EINECS	Contact for details

Quality Control

Our H-Pro-His-Val-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and chiral purity analysis. We provide full traceability and a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. The product meets stringent standards suitable for research and cGMP manufacturing applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Assay	95.0% - 105.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.