Description

H-Pro-His-Leu-Oh is a high-purity tripeptide derivative featuring a C-terminal carboxylic acid. This compound serves as a critical building block and reference standard in advanced biochemical research and pharmaceutical development. It is primarily utilized by researchers and manufacturers in the fields of peptide synthesis, proteomics, and enzyme inhibitor studies.

Application

• Pharmaceutical Intermediate: Used in the research and development of novel peptide-based therapeutics and active pharmaceutical ingredients (APIs).
• Biochemical Research: Acts as a substrate, inhibitor, or reference standard in enzymatic studies and proteomics research.
• Peptide Synthesis: Serves as a key building block (amino acid sequence: Pro-His-Leu) for the solid-phase or solution-phase synthesis of longer, more complex peptides.
• Protease/Enzyme Studies: Employed to investigate the specificity and kinetics of proteolytic enzymes like dipeptidyl peptidase (DPP) and other proteases.
• Academic & Industrial R&D: Utilized in university and corporate laboratories for fundamental research in biochemistry and medicinal chemistry.
• Quality Control Standard: Functions as a certified reference material (CRM) for analytical method development and validation in QC laboratories.

Basic Information

Product Name	H-Pro-His-Leu-Oh
CAS No.	83960-32-1
Molecular Formula	C19H28N6O5
Molecular Weight	420.47 g/mol
Synonyms	Pro-His-Leu; L-Prolyl-L-histidyl-L-leucine; H-Pro-His-Leu-OH; Pro-His-Leu-OH; L-Pro-L-His-L-Leu; Tripeptide Pro-His-Leu; (S)-2-((S)-1-((S)-2-Amino-1-hydroxy-4-methylpentylideneamino)-3-(1H-imidazol-5-yl)propyl)pyrrolidine-1-carboxylic acid
EINECS	Contact for details

Quality Control

Our H-Pro-His-Leu-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, MS). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines, as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the COA. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.