Description

H-Pro-His-Ala-Oh CAS NO 83960-31-0 is a synthetic tripeptide derivative, specifically a protected peptide fragment. This compound serves as a crucial building block in advanced peptide synthesis, offering researchers and manufacturers precise control over molecular structure. It is primarily utilized by the pharmaceutical, biotechnology, and life science research sectors for the development of novel therapeutic agents, diagnostic tools, and biochemical probes.

Application

• Pharmaceutical Intermediate: A key precursor in the solid-phase and solution-phase synthesis of complex peptide-based drugs and active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a standard or reference compound in proteomics, enzymology, and metabolic pathway studies.
• Peptide Library Construction: Essential for generating combinatorial peptide libraries for high-throughput screening in drug discovery.
• Cosmeceutical Development: Investigated for potential use in the formulation of bioactive skincare and anti-aging products.
• Enzyme Substrate/Analogue: Acts as a substrate or inhibitor model for studying enzyme kinetics and mechanisms, particularly those involving histidine and proline residues.
• Chemical Biology Tool: Employed in the synthesis of peptide conjugates for cell-penetration studies, targeted delivery, and biomarker identification.

Basic Information

Product Name	H-Pro-His-Ala-Oh
CAS No.	83960-31-0
Molecular Formula	C14H21N5O4
Molecular Weight	323.35 g/mol
Synonyms	L-Prolyl-L-histidyl-L-alanine; Pro-His-Ala-OH; H-Pro-His-Ala-OH; L-Pro-L-His-L-Ala; (S)-2-((S)-1-((S)-2-Amino-1-hydroxypropyl)-1H-imidazol-5-yl)-N-((S)-pyrrolidin-2-yl)formamide; Tripeptide Sequence Pro-His-Ala; Protected Pro-His-Ala Fragment
EINECS	Contact for details

Quality Control

Our H-Pro-His-Ala-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via mass spectrometry and IR spectroscopy. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and cGMP-grade material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccated environments.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.