Description

Gepirone CAS NO 83928-76-1 is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) belonging to the azapirone class of compounds. It is a selective 5-HT1A receptor partial agonist, which is the basis for its significant pharmacological interest. This compound is primarily required by pharmaceutical R&D laboratories and manufacturers engaged in the development and production of novel anxiolytic and antidepressant therapeutics.

Application

• Pharmaceutical API Synthesis: Serves as the core active ingredient in the manufacture of finished dosage forms for clinical evaluation and commercial production.
• Neuropharmacology Research: Used as a reference standard and tool compound in preclinical studies investigating serotonin (5-HT1A) receptor function and related neurological pathways.
• Anxiolytic Drug Development: A key intermediate in the research and production pipeline for next-generation anxiolytic medications with an improved side-effect profile.
• Antidepressant Formulations: Incorporated into developmental formulations aimed at treating major depressive disorder through serotonergic modulation.
• Chemical Reference Standard: Supplied to analytical and quality control laboratories for use in HPLC, LC-MS, and NMR method development and validation.
• Process Chemistry & Scale-Up: Utilized by process chemists for optimizing synthetic routes, impurity profiling, and scaling up production from laboratory to pilot plant scale.

Basic Information

Product Name	Gepirone
CAS No.	83928-76-1
Molecular Formula	C19H25N5O2
Molecular Weight	355.44 g/mol
Synonyms	Gepirone; 4,4-Dimethyl-1-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-2,6-piperidinedione; BMY-13805; MJ-13805; 2-[4-[4-(4,4-Dimethyl-2,6-dioxo-1-piperidinyl)butyl]-1-piperazinyl]pyrimidine; Azapirone; 1-Butyl-4,4-dimethyl-6-[4-(2-pyrimidinyl)piperazin-1-yl]piperidine-2,5-dione
EINECS	Contact for details

Quality Control

Our Gepirone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and impurity profiles, aligning with ICH guidelines. A Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and other critical parameters is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5%; Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.