Description

Trp-Nle-Arg-Phe-Nh2 is a synthetic peptide sequence of significant interest in biochemical and pharmacological research. This compound, identified by CAS number 83903-33-7, serves as a crucial tool for studying receptor-ligand interactions and signal transduction pathways. It is primarily utilized by research institutions and pharmaceutical developers focused on neuroscience, metabolic disorders, and peptide-based therapeutic discovery.

Application

• Biochemical Research: Used as a reference standard or active probe in studies of melanocortin receptors and related G-protein coupled receptors (GPCRs).
• Pharmacological Screening: Employed in high-throughput screening (HTS) assays to identify and characterize new agonists or antagonists.
• Drug Discovery: Serves as a key intermediate or structural template in the design and development of novel peptide therapeutics.
• Academic Studies: Utilized in university and institutional labs for fundamental research into appetite regulation, energy homeostasis, and pigmentation.
• Peptide Library Synthesis: Acts as a building block or a control sequence in the construction of combinatorial peptide libraries for activity mapping.

Basic Information

Product Name	Trp-Nle-Arg-Phe-Nh2
CAS No.	83903-33-7
Molecular Formula	C₃₈H₅₄N₁₂O₆
Molecular Weight	774.92 g/mol
Synonyms	Ac-Trp-Nle-Arg-Phe-NH₂; Ac-Tyr-Nle-Arg-Phe-NH₂ (common variant); Melanotan II fragment; MT-II fragment; N-Acetyl-Trp-Nle-Arg-Phe-amide; N-Acetyl-L-tryptophyl-L-norleucyl-L-arginyl-L-phenylalaninamide; α-MSH (4-10) analog; SHU-9119 analog
EINECS	Contact for details

Quality Control

Our Trp-Nle-Arg-Phe-Nh2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Amino Acid Analysis	± 10% of theoretical
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 70.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.