Description

Z-Phe-Pro-Nh2 is a protected dipeptide derivative, specifically the benzyloxycarbonyl (Z) protected form of phenylalanylprolinamide. This compound is a crucial building block in solid-phase peptide synthesis (SPPS), valued for its role in constructing more complex peptide sequences with high fidelity. It is primarily utilized by pharmaceutical R&D laboratories, biotech companies, and fine chemical manufacturers engaged in the development of peptide-based therapeutics, diagnostic agents, and biochemical tools.

Application

• Peptide Synthesis Intermediate: A key protected fragment for the controlled assembly of longer peptide chains in both research and GMP-scale production.
• Pharmaceutical Research: Used in the discovery and development of novel peptide drugs targeting metabolic disorders, cardiovascular diseases, and CNS conditions.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies, particularly those involving proteases like dipeptidyl peptidase-4 (DPP-4).
• Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in peptide analysis.
• Combinatorial Chemistry: A valuable component in libraries for screening bioactive compounds in drug discovery platforms.

Basic Information

Product Name	Z-Phe-Pro-Nh2
CAS No.	83871-06-1
Molecular Formula	C22H25N3O4
Molecular Weight	395.45 g/mol
Synonyms	Z-Phe-Pro-NH2; Z-Phenylalanylprolinamide; N-[(Benzyloxy)carbonyl]-L-phenylalanyl-L-prolinamide; CBZ-Phe-Pro-NH2; Cbz-L-Phenylalanyl-L-prolinamide; N-Carbobenzoxy-L-phenylalanyl-L-prolinamide; L-Phenylalanyl-L-prolinamide, N-[(benzyloxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our Z-Phe-Pro-Nh2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation by IR and NMR. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.