Description

2-[4-(Trifluoromethyl)Phenyl]Quinazolin-4(3H)-One is a high-value, fluorinated quinazolinone derivative, a key structural motif in advanced organic synthesis. This compound matters for its role as a versatile building block in the development of pharmaceuticals and agrochemicals, where the trifluoromethyl group is prized for its ability to modulate biological activity, lipophilicity, and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of potential drug candidates, particularly kinase inhibitors, anticancer agents, and central nervous system (CNS) active compounds.
• Agrochemical Research: Used as a building block for developing new herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the quinazolinone core and trifluoromethyl group.
• Material Science: Investigated for the creation of organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters or charge-transport layers, due to its conjugated structure.
• Chemical Biology & Proteomics: Employed in the design and synthesis of chemical probes and activity-based protein profiling (ABPP) agents for target identification and validation.
• Academic & Contract Research: Utilized in university and CRO (Contract Research Organization) laboratories for methodological studies in heterocyclic and fluoroorganic chemistry.
• Custom Synthesis & Scale-up: A starting material for custom synthesis projects, supporting process chemistry from milligram to kilogram scale for client-specific molecules.

Basic Information

Item	Details
Product Name	2-[4-(Trifluoromethyl)Phenyl]Quinazolin-4(3H)-One
CAS No.	83800-83-3
Molecular Formula	C15H9F3N2O
Molecular Weight	290.24 g/mol
Synonyms	4(3H)-Quinazolinone, 2-[4-(trifluoromethyl)phenyl]-; 2-(4-Trifluoromethylphenyl)-4(3H)-quinazolinone; 2-(4-(Trifluoromethyl)phenyl)quinazolin-4(3H)-one; 2-(α,α,α-Trifluoro-p-tolyl)-4-hydroxyquinazoline; 83800-83-3
EINECS	Contact for details

Quality Control

Our 2-[4-(Trifluoromethyl)Phenyl]Quinazolin-4(3H)-One is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our commitment to quality supports your research and development needs with reliable, high-purity materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials. This product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.