Description

4-Chloro-6-Isopropoxypyrimidine is a high-purity pyrimidine derivative, a key organic intermediate valued for its versatile reactivity. This compound is essential for the synthesis of complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and advanced agrochemicals. It is primarily sought by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel heterocyclic frameworks.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of various drug candidates, particularly those targeting kinase inhibition and other therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the pyrimidine core provides essential bioactivity.
• Chemical Research & Development: Serves as a versatile scaffold for medicinal chemistry and process chemistry in both academic and industrial laboratories.
• Material Science Precursor: Employed in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The chloro substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig amination.
• Nucleophilic Substitution: The isopropoxy group can be modified, allowing for further functionalization to create a diverse library of compounds.

Basic Information

Product Name	4-Chloro-6-Isopropoxypyrimidine
CAS No.	83774-13-4
Molecular Formula	C7H9ClN2O
Molecular Weight	172.61 g/mol
Synonyms	6-Isopropoxy-4-chloropyrimidine; 4-Chloro-6-(1-methylethoxy)pyrimidine; 4-Chloro-6-(propan-2-yloxy)pyrimidine; 4-Chloro-6-isopropyloxypyrimidine; Pyrimidine, 4-chloro-6-(1-methylethoxy)-; 4-Chloro-6-(isopropoxy)pyrimidine
EINECS	Contact for details

Quality Control

Our 4-Chloro-6-Isopropoxypyrimidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.