Description

2-Chloro-4-Ethoxypyrimidine is a versatile pyrimidine derivative, a crucial halogenated building block in advanced organic synthesis. Its core value lies in enabling the efficient construction of complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. This high-purity intermediate is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking reliable, scalable synthesis pathways.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of nucleoside analogs, kinase inhibitors, and other biologically active pyrimidine-based compounds.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators that incorporate the pyrimidine scaffold.
• Chemical Research & Development: Serves as a fundamental building block in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Material Science Precursor: Potential intermediate in the synthesis of organic electronic materials, ligands for catalysts, and specialty polymers.
• Cross-Coupling Reactions: The chloro substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, or Buchwald-Hartwig amination.
• Nucleophilic Substitution: The ethoxy group can be modified or displaced, offering a handle for further functionalization to create diverse chemical libraries.

Basic Information

Product Name	2-Chloro-4-Ethoxypyrimidine
CAS No.	83774-09-8
Molecular Formula	C6H7ClN2O
Molecular Weight	158.59 g/mol
Synonyms	4-Ethoxy-2-chloropyrimidine; 2-Chloro-4-ethoxypyrimidine; 2-Chloro-4-ethoxy-pyrimidine; Pyrimidine, 2-chloro-4-ethoxy-; 4-Ethoxy-2-chloro-pyrimidine
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Ethoxypyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.