Description

2(1H)-Pyrimidinone, 5-(Trifluoromethyl)- (9Ci) is a high-value, fluorinated pyrimidinone derivative that serves as a critical building block in advanced organic synthesis. Its trifluoromethyl group imparts unique electronic and steric properties, making it essential for modulating the biological activity and physicochemical characteristics of target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of antiviral, anticancer, and central nervous system (CNS) active drug candidates.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, where the CF3 group enhances lipophilicity and metabolic stability.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the development of specialty polymers and advanced organic electronic materials.
• Chemical Biology Probe: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and as a biochemical tool compound.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	2(1H)-Pyrimidinone, 5-(Trifluoromethyl)- (9Ci)
CAS No.	83767-80-0
Molecular Formula	C5H3F3N2O
Molecular Weight	164.09 g/mol
Synonyms	5-(Trifluoromethyl)pyrimidin-2(1H)-one; 5-(Trifluoromethyl)-2(1H)-pyrimidinone; 5-Trifluoromethyl-2-hydroxypyrimidine; 2-Hydroxy-5-(trifluoromethyl)pyrimidine; 5-Trifluoromethyluracil; 5-Trifluoromethyl-1H-pyrimidin-2-one; 83767-80-0
EINECS	Contact for details

Quality Control

Every batch of 2(1H)-Pyrimidinone, 5-(Trifluoromethyl)- is produced under strict quality management protocols. We provide comprehensive analytical data to ensure the material meets the precise requirements of research and development applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by validated methods (HPLC, NMR, GC) is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound is sensitive to fluoride and strong alkali; ensure it is stored separately from such materials to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.