Description

1-Methyl-2-Benzoylaminomethyl-5-Phenyl-1H-2,3-Dihydro-1,4-Benzodiazepi Ne Dihydrochloride is a high-purity, complex organic compound belonging to the benzodiazepine class, specifically formulated as a dihydrochloride salt for enhanced stability and handling. This compound is of significant interest for its role as a key pharmaceutical intermediate in the research and development of active pharmaceutical ingredients (APIs). It is primarily required by pharmaceutical manufacturers and contract research organizations (CROs) engaged in advanced synthetic chemistry and drug discovery programs.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel benzodiazepine-based active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new therapeutic agents.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Preclinical Studies: Employed in the early-stage pharmacological and toxicological evaluation of new drug candidates.
• Custom Synthesis: A starting material for the contract manufacturing of specialized, non-commercial chemical entities for research purposes.
• Chemical Library Development: Used to create diverse screening libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	1-Methyl-2-Benzoylaminomethyl-5-Phenyl-1H-2,3-Dihydro-1,4-Benzodiazepi Ne Dihydrochloride
CAS No.	83736-21-4
Molecular Formula	C24H24N4O·2HCl
Molecular Weight	457.39 g/mol (Free base: 384.48 g/mol)
Synonyms	1-Methyl-2-(benzoylamino)methyl-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepine dihydrochloride; 5-Phenyl-1-methyl-2-[(phenylcarbonyl)amino]methyl-2,3-dihydro-1H-1,4-benzodiazepine dihydrochloride; 1-Methyl-2-(N-benzoylaminomethyl)-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepine dihydrochloride; Benzodiazepine derivative 83736-21-4; 1,4-Benzodiazepine intermediate; Ro 07-9749 (dihydrochloride); Contact for additional trade names.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support development and cGMP-grade requirements, with documentation tailored to meet the rigorous standards of pharmaceutical and research clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccants or an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.