Description

(R)-Ampa CAS NO 83654-13-1 is a high-purity, stereochemically defined isomer of the potent glutamate receptor agonist AMPA, which is critical for neurological research. This compound serves as an essential pharmacological tool for studying the structure and function of ionotropic glutamate receptors (iGluRs) in the central nervous system. It is primarily needed by research institutions, pharmaceutical R&D departments, and biotechnology companies focused on neuroscience, neurodegenerative disease modeling, and the development of novel neuroprotective agents or CNS-targeted therapeutics.

Application

• Neuroscience Research: As a selective agonist for AMPA-type glutamate receptors to investigate synaptic plasticity, long-term potentiation (LTP), and excitatory neurotransmission.
• Pharmacological Studies: Used in receptor binding assays and functional studies to characterize receptor subtypes and screen for potential antagonists or modulators.
• Disease Model Development: Applied in cellular and animal models to study excitotoxicity related to stroke, epilepsy, and neurodegenerative conditions like Alzheimer's disease.
• Drug Discovery Pipeline: A key reference standard and tool compound in the discovery and validation stages for CNS-targeting pharmaceuticals.
• Biochemical Assays: Utilized in vitro to study the kinetics and mechanisms of glutamate receptor activation and desensitization.
• Academic Research: Fundamental tool for university laboratories exploring the molecular basis of learning, memory, and neurological disorders.

Basic Information

Product Name	(R)-Ampa
CAS No.	83654-13-1
Molecular Formula	C5H9NO4
Molecular Weight	147.13 g/mol
Synonyms	(R)-2-Amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid; (R)-AMPA; (R)-ATPA; (R)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; (R)-AMPAA; (R)-Form of AMPA; (R)-Isomer of AMPA; (R)-Glutamate receptor agonist AMPA
EINECS	Contact for details

Quality Control

Our (R)-Ampa is manufactured under strict quality control protocols to ensure high stereochemical purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is analyzed using advanced chromatographic and spectroscopic methods. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and identity is provided with every shipment, supporting compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% (R)-Isomer
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.