Description

(S)-Ampa CAS NO 83643-88-3 is a high-purity, stereochemically defined isomer of the potent glutamate receptor agonist α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA). This compound is a critical research tool for neuroscience and pharmacology, enabling the selective study of AMPA receptor subtypes and their role in synaptic transmission, plasticity, and neurological disorders. It is essential for academic researchers, pharmaceutical R&D teams, and diagnostic manufacturers focused on CNS drug discovery and neurochemical analysis.

Application

• Neuroscience Research: A selective agonist for studying the structure, function, and pharmacology of (S)-AMPA-preferring glutamate receptors in neuronal circuits.
• Pharmacological Studies: Used in in vitro and ex vivo assays to investigate receptor activation kinetics, desensitization, and allosteric modulation for drug screening.
• Neurodegenerative Disease Models: Applied in research models for conditions like Alzheimer's, Parkinson's, and ALS to understand excitotoxicity and glutamate system dysregulation.
• Diagnostic Development: Serves as a reference standard or key component in the development of assays and kits for neurological biomarker detection.
• Biochemical Tool: Used in receptor binding studies and the characterization of novel therapeutic compounds targeting the AMPA receptor.
• Academic & Industrial R&D: Fundamental reagent for universities, contract research organizations (CROs), and biopharmaceutical companies engaged in CNS-targeted innovation.

Basic Information

Product Name	(S)-Ampa
CAS No.	83643-88-3
Molecular Formula	C7H10N2O4
Molecular Weight	186.17 g/mol
Synonyms	(S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; (S)-AMPA; (2S)-2-Amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propanoic acid; L-AMPA; AMPA (S-isomer); (S)-ATPA; (S)-2-Amino-3-(5-methyl-3-hydroxy-1,2-oxazol-4-yl)propanoic acid
EINECS	Contact for details

Quality Control

Our (S)-Ampa is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure identity, potency, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with in-house specifications tailored for research use. We support traceability and data integrity for regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (S-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.