Description

L-Proline, 4-(Methylthio)-, trans- (9Ci) CAS NO 83624-61-7 is a non-proteinogenic, sulfur-containing proline derivative. This specialized amino acid analog is valued for its unique structure, which incorporates a methylthioether side chain, making it a valuable chiral building block and intermediate in advanced organic synthesis. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel bioactive compounds, peptidomimetics, and as a precursor for more complex heterocyclic systems.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new drug candidates, particularly for protease inhibitors and other targeted therapies.
• Peptidomimetics Research: Used to modify peptide backbones to enhance metabolic stability, bioavailability, and binding affinity in medicinal chemistry.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies to investigate biological pathways involving proline metabolism or sulfur biochemistry.
• Asymmetric Synthesis: Acts as a chiral auxiliary or building block in stereoselective synthesis to construct complex molecules with defined three-dimensional structures.
• Agrochemical Research: Investigated as a potential intermediate for developing novel plant growth regulators or herbicides with specific modes of action.

Basic Information

Product Name	L-Proline, 4-(Methylthio)-, trans- (9Ci)
CAS No.	83624-61-7
Molecular Formula	C7H13NO2S
Molecular Weight	175.25 g/mol
Synonyms	(2S,4R)-4-(Methylthio)proline; trans-4-(Methylthio)-L-proline; (2S,4R)-4-(Methylsulfanyl)proline; L-4-(Methylthio)proline; 4-Methylthio-L-proline; 4-Methylmercaptoproline; 4-(Methylthio)proline; (4R)-4-(Methylthio)-L-proline
EINECS	Contact for details

Quality Control

Our L-Proline, 4-(Methylthio)-, trans- (9Ci) is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the exacting standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.