Description

Cyclosporin H CAS NO 83602-39-5 is a specific, high-purity cyclosporin derivative, a cyclic undecapeptide of fungal origin. This compound is a critical reference standard and research tool in immunology and pharmacology, primarily valued for its role as a potent antagonist of the cyclophilin-Cyclosporin A complex. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require precise molecular tools for studying immunosuppressive pathways, developing assays, and advancing drug discovery programs.

Application

• Pharmacological Research: Used as a key reference standard and antagonist in studies of immunosuppression, T-cell activation, and cyclophilin-mediated signal transduction pathways.
• Biochemical Assay Development: Serves as a critical component in developing and validating high-throughput screening (HTS) assays for drug discovery targeting immunophilins.
• Pharmaceutical Reference Standard: Employed as a certified reference material (CRM) for quality control and analytical method development in the production of related pharmaceutical compounds.
• Mechanism of Action Studies: Utilized to elucidate the specific binding interactions and inhibitory mechanisms of cyclosporin analogs, aiding in structure-activity relationship (SAR) studies.
• Academic & Institutional Research: Supports fundamental research in immunology, molecular biology, and medicinal chemistry within university and government laboratories.

Basic Information

Product Name	Cyclosporin H
CAS No.	83602-39-5
Molecular Formula	C62H111N11O12
Molecular Weight	1202.6 g/mol
Synonyms	Cyclosporin H; [Thr2,Leu5, D-Hiv8, Leu10]-Cyclosporin A; [Melle4]Cyclosporin A; Cyclosporin Dihydrogen Sulfate (ambiguous); IMM 125; (2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S)-5-Ethyl-11-(1-hydroxy-2-methylbut-3-en-1-yl)-17,20,29,32-tetraisopropyl-8,14,23,26-tetramethyl-2,4,7,10,13,16,19,22,25,28,31-undecaoxo-3,6,9,12,15,18,21,24,27,30-decaazatritriacontan-33-oic Acid; [D-Hiv]2-[Leu]5-[Leu]10-CsA
EINECS	Contact for details

Quality Control

Our Cyclosporin H is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the exacting standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.