Description

2-(N'-Acetylphenylalanylamino)Ethyl-2'-Pyridyl Disulfide is a specialized heterobifunctional crosslinking agent featuring a protected amino group and a reactive disulfide bond. This compound is critical for creating reversible, cleavable linkages in bioconjugation strategies, particularly in the development of antibody-drug conjugates (ADCs) and other targeted therapeutics. It is primarily utilized by research scientists and process development teams in the pharmaceutical and biotechnology sectors for site-specific protein modification and controlled drug delivery systems.

Application

• Bioconjugation Reagent: A key intermediate for the site-specific modification of proteins, peptides, and antibodies.
• Antibody-Drug Conjugate (ADC) Development: Used to create cleavable linkers that release payloads in the reducing environment of target cells.
• Controlled Drug Delivery Systems: Enables the design of stimuli-responsive nanocarriers and prodrugs.
• Protein Immobilization: Facilitates the reversible attachment of proteins to surfaces for biosensor and diagnostic assay development.
• Peptide Chemistry: Serves as a building block in solid-phase peptide synthesis for introducing disulfide bridges.
• Research Tool: Employed in biochemical and biophysical studies to investigate protein structure, function, and interactions.

Basic Information

Product Name	2-(N'-Acetylphenylalanylamino)Ethyl-2'-Pyridyl Disulfide
CAS No.	83578-20-5
Molecular Formula	C20H23N3O3S2
Molecular Weight	417.54 g/mol
Synonyms	N-α-Acetyl-L-phenylalanine N'-succinimidyl ester 2-pyridyl disulfide derivative; Ac-Phe-OSu 2-PDS; S-(2-Pyridyldithio)-N-ethyl-N'-(N-α-acetylphenylalanyl)urea; Heterobifunctional crosslinker (Ac-Phe-OSu/2-PDS); 2-Pyridyldithioethyl N-succinimidyl N-α-acetylphenylalaninate; SPDP derivative of Ac-Phe-OSu; N-Succinimidyl 3-(2-pyridyldithio)propionamidoacetylphenylalaninate analog; Acetylphenylalanyl-PDPH
EINECS	Contact for details

Quality Control

Our 2-(N'-Acetylphenylalanylamino)Ethyl-2'-Pyridyl Disulfide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for research and process development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee reproducibility and traceability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and hydrolysis. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation. For long-term storage, desiccate.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.