Description

N(Epsilon)-Decanoylglucagon is a chemically modified peptide derivative of the glucagon hormone, where a decanoyl group is attached to the ε-amino group of a lysine residue. This modification is crucial for enhancing the molecule's stability, lipophilicity, and biological activity profile, making it a valuable tool in metabolic research and therapeutic development. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on diabetes, obesity, and metabolic disorder studies.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or reference standard in the development of novel glucagon receptor agonists or antagonists for metabolic diseases.
• Biochemical Studies: Used to investigate the structure-activity relationships (SAR) of glucagon analogs and the impact of lipidation on peptide hormone function and stability.
• Metabolic Pathway Analysis: Employed in in vitro and in vivo models to study glucose metabolism, hepatic function, and energy homeostasis.
• Prototype Therapeutic Agent: Acts as a candidate molecule in preclinical studies for potential therapies targeting type 2 diabetes and related conditions.
• Diagnostic Tool Development: May be used in the development of assays and diagnostic kits for measuring glucagon-like activity or related biomarkers.

Basic Information

Product Name	N(Epsilon)-Decanoylglucagon
CAS No.	83512-38-3
Molecular Formula	C169H251N43O49S
Molecular Weight	~3483.1 g/mol
Synonyms	Decanoyl-Glucagon; Nε-Decanoylglucagon; Glucagon Decanoate; Glucagon C10-Lipidated; Lipoglucagon; Acylated Glucagon Analog; Glucagon Derivative; 83512-38-3
EINECS	Contact for details

Quality Control

Our N(Epsilon)-Decanoylglucagon is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing all specifications and test results to ensure compliance with your research or development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by amino acid analysis)
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 2.0%
Biological Activity	Assessed by in vitro assay (Contact for details)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.