Description

Conotoxin M I (Reduced) is a chemically modified, reduced form of the ω-conotoxin M I peptide, a potent and selective N-type calcium channel blocker. This reduced variant is a critical intermediate for biochemical research and pharmaceutical development, particularly in the study of neuronal signaling and pain pathways. It is primarily utilized by research institutions, biotechnology companies, and pharmaceutical developers focused on neuroscience, analgesic drug discovery, and ion channel pharmacology.

Application

• Neuroscience Research: As a key tool compound for studying the function and modulation of N-type (CaV2.2) voltage-gated calcium channels in neuronal circuits.
• Analgesic Drug Discovery: Serves as a reference standard and pharmacological probe in the development of novel non-opioid pain therapeutics targeting calcium channels.
• Biochemical Assay Development: Used in the calibration and validation of high-throughput screening (HTS) assays designed to identify new channel modulators.
• Peptide Chemistry & Conjugation: Acts as a foundational scaffold or intermediate for further chemical modifications, labeling (e.g., with fluorophores or biotin), or structure-activity relationship (SAR) studies.
• Toxicology & Safety Pharmacology: Employed to investigate the specific effects of calcium channel inhibition in various experimental models.

Basic Information

Product Name	Conotoxin M I (Reduced)
CAS No.	83481-45-2
Molecular Formula	C102H172N36O32S7
Molecular Weight	2527.1 g/mol
Synonyms	ω-Conotoxin M I (Reduced); Reduced ω-Conotoxin M I; ω-Conotoxin M I, reduced form; ω-Ctx M I (Reduced); Conotoxin M I disulfide reduced; ω-Conotoxin M I (disulfide bridges reduced); ω-Conotoxin M I (Reduced); CaV2.2 Channel Blocker (Reduced Form)
EINECS	Contact for details

Quality Control

Every batch of Conotoxin M I (Reduced) is manufactured and analyzed under strict quality protocols to ensure identity, purity, and consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed results for purity (HPLC), molecular weight confirmation (MS), and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Molecular Weight	2527.1 ± 2 Da
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water or aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.