Description

((2R,4S,5R)-4-(tert-Butyldiphenylsilyloxy)-5-(Hydroxymethyl)-Tetrahydrofuran-2-Yl)-5-Methylpyrimidine-2,4(1H,3H)-Dione is a high-purity, advanced pharmaceutical intermediate featuring a protected nucleoside structure. This compound is critical for the synthesis of modified nucleosides and nucleotides, serving as a key building block in the development of antiviral and anticancer therapeutics. It is primarily required by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the production of active pharmaceutical ingredients (APIs) and oligonucleotides.

Application

• Antiviral Drug Synthesis: A crucial protected intermediate in the production of nucleoside analog antiviral agents.
• Oligonucleotide Manufacturing: Used as a phosphoramidite precursor for solid-phase synthesis of modified DNA/RNA strands in antisense and siRNA therapies.
• Cancer Research Compounds: Serves as a building block for developing nucleoside-based chemotherapeutic agents and targeted cancer treatments.
• Prodrug Development: Employed in creating prodrug forms of nucleoside analogs to enhance bioavailability and targeting.
• Biochemical Research: Utilized in enzymatic studies and as a substrate for investigating nucleotide metabolism pathways.
• Labeled Compound Production: Acts as a starting material for synthesizing isotopically labeled (e.g., 13C, 15N) nucleosides for metabolic tracing and imaging.

Basic Information

Product Name	((2R,4S,5R)-4-(tert-Butyldiphenylsilyloxy)-5-(Hydroxymethyl)-Tetrahydrofuran-2-Yl)-5-Methylpyrimidine-2,4(1H,3H)-Dione
CAS No.	83467-48-5
Molecular Formula	C27H32N2O5Si
Molecular Weight	492.65 g/mol
Synonyms	5-Methyl-2'-deoxyuridine 5'-O-(tert-butyldiphenylsilyl) ether; TBDPS-protected 5-Methyldeoxyuridine; 5'-O-TBDPS-5-methyl-2'-deoxyuridine; 1-[(2R,4S,5R)-4-[(tert-Butyldiphenylsilyl)oxy]-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione; Protected 5-Methyldeoxyuridine; Thymidine 5'-O-tert-butyldiphenylsilyl ether; 5-Methyl-2'-deoxyuridine, 5'-O-(1,1-dimethylethyl)diphenylsilyl derivative
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up processes. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development under cGMP guidelines where required for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from fluoride sources and strong alkali.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.