Description

Substance P, Arg(1)-Pro(2)-Trp(7,9)- CAS NO 83440-04-4 is a synthetic, biologically active peptide analog of the neuropeptide Substance P, specifically modified at positions 1, 2, 7, and 9. This compound is of significant value for advanced research in neuropharmacology and signal transduction due to its potent and selective interaction with neurokinin receptors. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on developing novel therapeutics for pain management, inflammation, and neurological disorders.

Application

• Neuroscience Research: A critical tool for studying the role of Substance P and neurokinin-1 (NK1) receptors in pain signaling, neurogenic inflammation, and central nervous system function.
• Drug Discovery & Screening: Used as a reference standard or active ligand in high-throughput screening (HTS) assays to identify and characterize new NK1 receptor antagonists.
• Pharmacological Studies: Employed in in vitro and in vivo models to investigate receptor binding affinity, agonist/antagonist activity, and downstream cellular pathways.
• Biochemical Assay Development: Serves as a key component in developing and validating ELISA, RIA, or other immunoassays targeting Substance P and its metabolites.
• Academic & Clinical Research: Supports fundamental research into conditions like migraine, arthritis, depression, and nausea, where the Substance P pathway is implicated.

Basic Information

Product Name	Substance P, Arg(1)-Pro(2)-Trp(7,9)-
CAS No.	83440-04-4
Molecular Formula	C63H98N20O13S
Molecular Weight	1359.65 g/mol
Synonyms	[Arg1, Pro2, Trp7,9]-Substance P; Substance P (1-11), [Arg1, Pro2, Trp7,9]-; [Arg1,Pro2,Trp7,9]-SP; Modified Substance P analog; Neurokinin receptor ligand; NK1 receptor agonist/antagonist research compound; SP analog (Arg1, Pro2, Trp7,9)
EINECS	Contact for details

Quality Control

Our Substance P analog is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and mass spectrometry for identity confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our commitment to consistent quality and batch-to-batch reproducibility supports reliable experimental outcomes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Solubility	Soluble in water, dimethyl sulfoxide (DMSO)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.