Description

4-Chloro-5-Iodo-2,6-Dimethylpyrimidine is a halogenated pyrimidine derivative, a versatile and highly functionalized heterocyclic building block. Its molecular structure, featuring both chloro and iodo substituents, makes it a critical intermediate for synthesizing complex molecules in advanced research and development. This compound is primarily sought after by pharmaceutical and agrochemical R&D teams for constructing active ingredients, as well as by academic and industrial chemists developing novel materials and ligands.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in antiviral, anticancer, and central nervous system (CNS) therapeutic research.
• Agrochemical Synthesis: Used to build advanced fungicides, herbicides, and insecticides, leveraging its halogenated pyrimidine core for biological activity.
• Chemical Research & Development: Serves as a versatile scaffold for medicinal chemistry, enabling structure-activity relationship (SAR) studies and library synthesis.
• Material Science: A potential building block for creating organic electronic materials, ligands for metal-organic frameworks (MOFs), and specialty polymers.
• Cross-Coupling Reactions: The iodo substituent is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to introduce complex aryl or alkynyl groups.
• Nucleoside Analogue Synthesis: Used in the development of modified nucleosides and nucleotides for biochemical and therapeutic applications.

Basic Information

Product Name	4-Chloro-5-Iodo-2,6-Dimethylpyrimidine
CAS No.	83410-16-6
Molecular Formula	C6H6ClIN2
Molecular Weight	284.48 g/mol
Synonyms	5-Iodo-4-chloro-2,6-dimethylpyrimidine; 2,6-Dimethyl-4-chloro-5-iodopyrimidine; 4-Chloro-5-iodo-2,6-dimethylpyrimidine; 4-Chloro-5-iodo-2,6-lutidine; Pyrimidine, 4-chloro-5-iodo-2,6-dimethyl-
EINECS	Contact for details

Quality Control

Our 4-Chloro-5-Iodo-2,6-Dimethylpyrimidine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and process development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials. Due to its light-sensitive nature, containers should be amber glass or opaque.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.