Description

5-[3-[(4'-Chloro[1,1'-Biphenyl]-4-Yl)Oxy]Propoxy]-6-Methylpyrimidine-2,4-Diamine Hydrochloride is a high-purity, complex organic salt with significant value as a key pharmaceutical intermediate. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of novel therapeutic agents. It is primarily sought by pharmaceutical manufacturers, contract research organizations (CROs), and advanced chemical synthesis laboratories requiring reliable, high-quality building blocks for drug discovery and process development.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of active pharmaceutical ingredients (APIs) and potential drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for developing new therapeutic molecules.
• Process Chemistry & Scale-Up: Employed in route scouting and process development for efficient, scalable API manufacturing.
• Reference Standard: Acts as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical analysis.
• Biochemical Research: Potential use as a tool compound for investigating biological pathways and enzyme interactions in vitro.
• Custom Synthesis: A starting material for the custom synthesis of more complex, target-specific chemical entities for client projects.

Basic Information

Item	Details
Product Name	5-[3-[(4'-Chloro[1,1'-Biphenyl]-4-Yl)Oxy]Propoxy]-6-Methylpyrimidine-2,4-Diamine Hydrochloride
CAS No.	83402-97-5
Molecular Formula	C26H26ClN5O2·HCl
Molecular Weight	520.88 g/mol
Synonyms	5-[3-[(4'-Chloro[1,1'-biphenyl]-4-yl)oxy]propoxy]-6-methyl-2,4-pyrimidinediamine hydrochloride; 6-Methyl-5-[3-[(4'-chloro-4-biphenylyl)oxy]propoxy]-2,4-pyrimidinediamine monohydrochloride; Biphenylpyrimidine diamine hydrochloride; CAS 83402-97-5; 5-(3-((4'-Chloro-[1,1'-biphenyl]-4-yl)oxy)propoxy)-6-methylpyrimidine-2,4-diamine hydrochloride
EINECS	Contact for details

Quality Control

Our 5-[3-[(4'-Chloro[1,1'-Biphenyl]-4-Yl)Oxy]Propoxy]-6-Methylpyrimidine-2,4-Diamine Hydrochloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical intermediate use. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.