Description

Cholecystokinin 58 is a bioactive peptide fragment derived from the larger cholecystokinin hormone, specifically corresponding to the C-terminal 58 amino acid sequence. This compound is of significant value in biochemical and pharmacological research for studying receptor binding, signal transduction, and digestive system functions. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic manufacturers focused on gastrointestinal physiology and neuroendocrinology.

Application

• Biochemical Research: Used as a high-purity reference standard and tool compound for studying cholecystokinin receptor (CCK-R) subtypes and their downstream signaling pathways.
• Pharmacological Studies: Employed in in vitro and in vivo assays to investigate the role of CCK in pancreatic secretion, gallbladder contraction, and gut motility.
• Diagnostic Development: Serves as a critical antigen or calibrator in the development of immunoassays (ELISA, RIA) for measuring CCK levels in biological samples.
• Neuroscience Research: Applied in studies exploring the satiety effects and behavioral roles of CCK in the central nervous system.
• Drug Discovery: Acts as a lead compound or benchmark for designing and screening novel therapeutic agents targeting CCK receptors for conditions like obesity, anxiety, or pancreatitis.
• Academic & Clinical Studies: Utilized in university and hospital laboratories to further understand the pathophysiology of digestive disorders and metabolic diseases.

Basic Information

Product Name	Cholecystokinin 58
CAS No.	83381-92-4
Molecular Formula	C254H381N67O69S2
Molecular Weight	~5740.4 g/mol
Synonyms	CCK-58; Cholecystokinin (58-115) (human); Cholecystokinin-58; CCK 58; CCK58; CCK (58-115); Human cholecystokinin (58-115); Pancreozymin fragment (58-115).
EINECS	Contact for details

Quality Control

Our Cholecystokinin 58 is manufactured under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including reversed-phase HPLC for purity assessment and mass spectrometry for identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the purity, peptide content, and results of related substance tests.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.