Description

Substance P (4-11), Pro(4)-Trp(7,9,10)- CAS NO 83334-92-3 is a specific, biologically active fragment of the neuropeptide Substance P, designed for enhanced receptor selectivity and stability. This synthetic analog is crucial for advanced research in neuropharmacology and signal transduction, offering a valuable tool for studying tachykinin receptor function and modulation. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on neuroscience, pain management, and inflammatory pathways.

Application

• Neuroscience Research: A key tool for investigating the role of Substance P and its receptors (NK1, NK2, NK3) in the central and peripheral nervous systems.
• Pharmacological Studies: Used in receptor binding assays, functional activity tests, and structure-activity relationship (SAR) studies to develop novel therapeutics.
• Pain and Inflammation Models: Employed in preclinical research to study neurogenic inflammation, nociception, and the development of analgesic drugs.
• Cell Signaling Pathways: Utilized to elucidate intracellular signaling cascades activated by tachykinin receptors in various cell types.
• Biochemical Reagent: Serves as a reference standard and active component in specialized assay kits and diagnostic development.

Basic Information

Product Name	Substance P (4-11), Pro(4)-Trp(7,9,10)-
CAS No.	83334-92-3
Molecular Formula	C58H74N14O9
Molecular Weight	1087.3 g/mol
Synonyms	Substance P Fragment 4-11, [pGlu4, Trp7,9,10]-Substance P (4-11); [pGlu4, Trp7,9,10]-SP (4-11); SP (4-11) analog; Tachykinin receptor ligand; Neurokinin receptor peptide; Arg-Pro-Lys-Pro-Gln-Gln-Trp-Phe-Trp-Trp-Leu-Met-NH2 (modified)
EINECS	Contact for details

Quality Control

Our Substance P (4-11), Pro(4)-Trp(7,9,10)- is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and mass spectrometry for identity confirmation, to ensure it meets the exacting standards required for research and development. Certificates of Analysis (COA) with full chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.