Description

Dynorphin (1-32) CAS NO 83328-95-4 is a bioactive peptide fragment of the endogenous opioid peptide dynorphin A, known for its potent and selective activity at κ-opioid receptors. This high-purity reference standard is critical for neuroscience and pharmaceutical research, enabling precise study of pain modulation, addiction pathways, and neuropsychiatric disorders. It is an essential tool for researchers and developers in neuropharmacology, molecular biology, and the development of novel central nervous system (CNS) therapeutics.

Application

• Neuroscience Research: Used as a selective κ-opioid receptor (KOR) agonist to study receptor signaling, neuroplasticity, and behavioral effects in animal models.
• Pain Research: A key tool for investigating the complex role of the dynorphin system in pro-nociceptive and anti-nociceptive pathways.
• Psychiatric & Addiction Studies: Applied in research on stress, depression, anxiety, and substance use disorders due to its dysphoric and aversive effects mediated by KOR activation.
• Biochemical Assay Development: Serves as a standard for calibrating receptor binding assays (e.g., radioligand binding), functional cellular assays, and ELISA kits.
• Pharmaceutical R&D: Used in the screening and characterization of novel KOR antagonists or modulators for therapeutic development.
• Academic & Institutional Research: A fundamental reagent for university and government labs conducting basic research on opioid peptide systems.

Basic Information

Product Name	Dynorphin (1-32)
CAS No.	83328-95-4
Molecular Formula	C185H285N55O52S
Molecular Weight	4067.6 g/mol
Synonyms	Dynorphin A (1-32); Dynorphin-32; Big Dynorphin; Leumorphin; Dynorphin A 1-32 amide; Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln-Lys-Arg-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Gln-Phe-Lys-Val-Val-Thr; [Leu5, Arg6, Arg7]-Enkephalin-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln.
EINECS	Contact for details

Quality Control

Our Dynorphin (1-32) is manufactured under strict quality systems suitable for research applications. Each batch undergoes rigorous analytical testing, including HPLC for purity verification and mass spectrometry for identity confirmation. We provide comprehensive Certificates of Analysis (COA) detailing purity, content, and analytical results to ensure traceability and meet the stringent requirements of scientific research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Aliquot to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.