Description

2-Mercaptoacetyl-Phenylalanylleucine is a synthetic peptide derivative featuring a thiol-functionalized acetyl group. This compound is of significant interest in pharmaceutical research and development, particularly as a key intermediate or building block for novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of protease inhibitors and other bioactive peptides.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel drug candidates, particularly protease inhibitors.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate protease activity and mechanism.
• Peptide Chemistry: Acts as a specialized precursor for the solid-phase or solution-phase synthesis of complex, thiol-containing peptide sequences.
• Drug Discovery: Employed in high-throughput screening libraries and medicinal chemistry programs to explore new pharmacophores.
• Chemical Biology Tool: Utilized for studying protein-protein interactions or for the development of activity-based probes targeting specific enzymes.

Basic Information

Product Name	2-Mercaptoacetyl-Phenylalanylleucine
CAS No.	83328-02-3
Molecular Formula	C20H29N3O4S
Molecular Weight	407.53 g/mol
Synonyms	2-Mercaptoacetyl-Phe-Leu; N-(2-Mercaptoacetyl)-L-phenylalanyl-L-leucine; Mercaptoacetyl-Phenylalanine-Leucine; Ac-SCH2-CO-Phe-Leu-OH; (2S)-2-[[(2S)-2-[(2-Sulfanylacetyl)amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid; MAPL; Thioacetyl-Phe-Leu
EINECS	Contact for details

Quality Control

Our 2-Mercaptoacetyl-Phenylalanylleucine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure stereochemical integrity. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific research or cGMP guidelines upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) for long-term stability, as the compound is easily oxidized and light-sensitive. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.