Description

Pth (28-48) (Human) is a synthetic peptide fragment corresponding to amino acid residues 28-48 of the human parathyroid hormone. This high-purity peptide is a critical research tool for studying calcium metabolism, bone biology, and endocrine signaling pathways. It is essential for researchers and developers in the fields of pharmaceutical R&D, biochemical research, and diagnostic assay development.

Application

• Biochemical Research: Used as a reference standard and active agent in studies of parathyroid hormone (PTH) receptor binding, signal transduction, and structure-activity relationships (SAR).
• Pharmaceutical Development: Serves as a key intermediate or reference compound in the development of novel therapeutics for osteoporosis, hyperparathyroidism, and other bone mineral disorders.
• Diagnostic Assay Development: Employed in the calibration and validation of immunoassays (e.g., ELISA) designed to detect and quantify PTH or related biomarkers in clinical samples.
• Cell Culture & In Vitro Studies: Applied in cell-based assays to investigate the biological effects of PTH fragments on osteoblast and osteoclast activity.
• Antibody Production: Utilized as an immunogen for generating specific polyclonal or monoclonal antibodies against the human PTH sequence.

Basic Information

Product Name	Pth (28-48) (Human)
CAS No.	83286-22-0
Molecular Formula	C98H155N31O26
Molecular Weight	2208.5 g/mol
Synonyms	Human Parathyroid Hormone (28-48); hPTH (28-48); PTH (28-48); Parathyroid Hormone Fragment (28-48); H-Val-Ala-Leu-Gly-Ala-Pro-Leu-Pro-Pro-Arg-Asp-Pro-Gly-Ala-Ser-Val-Leu-Arg-Lys-Lys-Leu-Gln-OH; [Ala28,29,31,33,34,37]hPTH(28-48); Synthetic human PTH(28-48) peptide
EINECS	Contact for details

Quality Control

Our Pth (28-48) (Human) is manufactured under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). Certificates of Analysis (COA) detailing all specifications are provided to guarantee compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Composition	Within ±10% of theoretical
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.