Description

Enkephalin, H-Tyr-Cyclo-(N(Delta)-Orn-Gly-Phe-Leu)- is a synthetic, cyclic pentapeptide analog of the endogenous opioid peptide enkephalin, designed for enhanced metabolic stability and receptor selectivity. This compound is a critical research tool for investigating opioid receptor pharmacology, pain modulation pathways, and neurobiological signaling. It is essential for pharmaceutical R&D, academic neuroscience research, and the development of novel therapeutic agents targeting the central nervous system.

Application

• Neuroscience Research: A key ligand for studying the structure, function, and signaling mechanisms of delta (δ) and mu (μ) opioid receptors in vitro and in vivo.
• Analgesic Drug Discovery: Serves as a lead compound or reference standard in the development of new, non-addictive pain management therapies with improved side-effect profiles.
• Biochemical Assays: Used in competitive binding assays, receptor autoradiography, and functional studies (e.g., cAMP inhibition, GTPγS binding) to characterize novel compounds.
• Metabolic Stability Studies: Employed as a model peptide to evaluate the effects of cyclization on resistance to enzymatic degradation (e.g., by aminopeptidases).
• Academic & Institutional Research: Fundamental reagent for university and government labs exploring neuropeptides, pain pathways, and opioid system biology.
• Biopharmaceutical Reference Standard: Used for quality control, method development, and validation in analytical laboratories within the biopharma sector.

Basic Information

Product Name	Enkephalin, H-Tyr-Cyclo-(N(Delta)-Orn-Gly-Phe-Leu)-
CAS No.	83159-95-9
Molecular Formula	C34H45N7O7
Molecular Weight	663.77 g/mol
Synonyms	Cyclo[Nδ-ornithyl-glycyl-phenylalanyl-leucyl]tyrosine; H-Tyr-c[D-Orn-Gly-Phe-Leu]; Tyr-c[D-Orn-Gly-Phe-Leu]; Cyclic Enkephalin Analog; [D-Orn2]Cycloleu-enkephalin; c[D-Orn-Gly-Phe-Leu]Tyr; Opioid Peptide Analog 83159-95-9
EINECS	Contact for details

Quality Control

Our Enkephalin, H-Tyr-Cyclo-(N(Delta)-Orn-Gly-Phe-Leu)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.