Description

Isodityrosine CAS NO 83118-65-4 is a non-proteinogenic amino acid derivative formed by the oxidative coupling of two tyrosine residues. This compound is of significant interest as a biomarker for oxidative stress and protein cross-linking in biological systems. It serves as a critical reference standard and research chemical for scientists in the fields of biochemistry, proteomics, and pharmaceutical development. Its unique structure makes it essential for studying age-related diseases, connective tissue disorders, and the stability of therapeutic proteins.

Application

• Biomedical Research: Used as a key biomarker and analytical standard in studies of oxidative damage, protein aging, and neurodegenerative diseases like Alzheimer's.
• Pharmaceutical Development: Employed in stability testing and formulation studies of protein-based drugs (biologics) to understand and mitigate aggregation and degradation pathways.
• Proteomics & Diagnostics: Acts as a reference compound in mass spectrometry and HPLC methods for the identification and quantification of protein modifications in clinical samples.
• Nutritional Science: Investigated for its role in food proteins, particularly in assessing the effects of processing on protein quality and digestibility.
• Cosmeceutical Research: Studied for its implications in skin aging, as it is a marker of collagen and elastin cross-linking caused by UV radiation and environmental stress.
• Enzymology Studies: Utilized to investigate the activity of peroxidases and other enzymes involved in the formation of dityrosine cross-links.

Basic Information

Product Name	Isodityrosine
CAS No.	83118-65-4
Molecular Formula	C18H18N2O6
Molecular Weight	358.35 g/mol
Synonyms	3,3'-Dityrosine; Bis-tyrosine; Dityrosine Isomer; L-Isodityrosine; 2,2'-Bis(4-hydroxyphenyl)-3,3'-bipyrrole-5,5'-dicarboxylic Acid; 3-(3,5-Diiodo-4-hydroxyphenyl)alanine; Oxidized Tyrosine Dimer; (R,R)-Isodityrosine
EINECS	Contact for details

Quality Control

Our Isodityrosine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS). We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade standards. Specifications are designed to meet the rigorous demands of analytical and life science laboratories.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a desiccated environment away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.