Description

1-n-((S)-4-Amino-2-Hydroxybutyryl)-2''-Deoxykanamycin B is a semisynthetic derivative of the aminoglycoside antibiotic kanamycin B, specifically modified to enhance its pharmacological profile. This compound is of significant interest for its potential to overcome certain bacterial resistance mechanisms while maintaining potent antibacterial activity. It is primarily utilized by pharmaceutical researchers and manufacturers in the development of advanced antibiotic therapies and as a critical reference standard for quality control and analytical studies.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of next-generation aminoglycoside antibiotics.
• Biochemical Research: Used as a reference compound in studies investigating bacterial ribosome interaction, antibiotic resistance, and structure-activity relationships (SAR).
• Quality Control & Analytical Standards: Essential as a high-purity certified reference material (CRM) for HPLC, LC-MS, and other analytical methods in pharmaceutical quality assurance labs.
• Antimicrobial Agent Development: Investigated for its efficacy against multidrug-resistant Gram-negative and Gram-positive bacterial strains.

Basic Information

Product Name	1-n-((S)-4-Amino-2-Hydroxybutyryl)-2''-Deoxykanamycin B
CAS No.	83071-96-9
Molecular Formula	C23H46N6O13
Molecular Weight	614.65 g/mol
Synonyms	1-N-[(S)-4-Amino-2-hydroxybutyryl]-2''-deoxykanamycin B; 2''-Deoxy-1-N-[(S)-4-amino-2-hydroxybutyryl]kanamycin B; Arbekacin Impurity; Arbekacin Related Compound A; (S)-4-Amino-2-hydroxybutyryl-2''-deoxykanamycin B; 1-N-(L-4-Amino-2-hydroxybutyryl)-2''-deoxykanamycin B
EINECS	Contact for details

Quality Control

Our 1-n-((S)-4-Amino-2-Hydroxybutyryl)-2''-Deoxykanamycin B is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical research and reference standard applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccants or an inert atmosphere to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.