Description

Nafamostat Mesylate CAS NO 82956-11-4 is a synthetic serine protease inhibitor of the guanidinobenzoate ester class. This compound is of significant commercial and research interest due to its potent anticoagulant and anti-inflammatory properties. It is primarily required by pharmaceutical manufacturers and research institutions for the development of therapeutic agents and as a critical biochemical tool in protease-related studies.

Application

• Pharmaceutical Intermediate: Key raw material in the synthesis of anticoagulant and anti-inflammatory drugs.
• Protease Research: Essential biochemical reagent for studying serine protease mechanisms and inhibition.
• Therapeutic Agent Development: Investigated for use in treating conditions like pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant in hemodialysis.
• In Vitro Diagnostics: Used in diagnostic kits and assays to measure blood coagulation parameters and protease activity.
• Academic & Biotech Research: Serves as a reference standard and active compound in life science research for cell signaling and inflammation pathways.

Basic Information

Product Name	Nafamostat Mesylate
CAS No.	82956-11-4
Molecular Formula	C19H17N5O2 • CH4O3S
Molecular Weight	347.38 (Free base) / 439.47 (Mesylate salt)
Synonyms	6-Amidino-2-naphthyl p-guanidinobenzoate dimethanesulfonate; FUT-175; Nafamostat; Futhan; Nafamostat Dimethanesulfonate; p-Guanidinobenzoic Acid 6-Amidino-2-naphthyl Ester Dimethanesulfonate; 4-Guanidinobenzoic Acid 6-Amidino-2-naphthyl Ester Methanesulfonate Salt
EINECS	Contact for details

Quality Control

Our Nafamostat Mesylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets high-grade standards suitable for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and residual solvents is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.