Description

Fmoc-Ser-OMe is a protected serine derivative, specifically the methyl ester of N-(9-fluorenylmethoxycarbonyl)-L-serine, widely used in solid-phase peptide synthesis (SPPS). This compound is a critical building block for the controlled assembly of peptides, offering orthogonal protection for the amino and carboxyl groups. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require high-purity amino acid derivatives for the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental Fmoc-protected amino acid for the sequential construction of custom peptide sequences.
• Pharmaceutical Research: Used in the discovery and development of peptide-based drugs, hormones, and vaccines.
• Bioconjugation: Serves as a key intermediate for creating peptide-protein or peptide-small molecule conjugates.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening of bioactive peptide leads.
• Biochemical Tool Development: Integral for synthesizing labeled peptides, enzyme substrates, or inhibitors for research.
• Academic & Industrial R&D: A staple reagent in laboratories focused on organic synthesis, medicinal chemistry, and molecular biology.

Basic Information

Product Name	Fmoc-Ser-OMe
CAS No.	82911-78-2
Molecular Formula	C19H19NO5
Molecular Weight	341.36 g/mol
Synonyms	Fmoc-L-serine methyl ester; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-serine methyl ester; Methyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-serinate; Fmoc-Serine-OMe; Fmoc-Ser(Me); (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-hydroxypropanoic acid methyl ester; Fmoc-Serinol methyl ester (common misnomer); FMOC-SER-OME
EINECS	Contact for details

Quality Control

Our Fmoc-Ser-OMe is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity verification, to ensure compliance with high-grade standards suitable for sensitive research and synthesis applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation [α]	Contact for details
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.