Description

L-Histidine, n-[(Phenylmethoxy)Carbonyl]-1-(Triphenylmethyl)- is a protected derivative of the essential amino acid L-Histidine, featuring orthogonal protecting groups for selective deprotection in complex peptide synthesis. This compound is critical for researchers and manufacturers requiring high-purity, advanced intermediates to build sophisticated peptide-based pharmaceuticals and bioactive molecules. It is primarily utilized by the pharmaceutical, biotechnology, and advanced research sectors for the development of novel therapeutic agents, including peptide hormones and targeted drug conjugates.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key, protected building block for the controlled incorporation of histidine residues into peptide chains.
• Pharmaceutical Intermediate: Used in the research and GMP-scale production of peptide-based active pharmaceutical ingredients (APIs).
• Bioconjugation Chemistry: Acts as a precursor for creating functionalized peptides for antibody-drug conjugates (ADCs) and other targeted therapies.
• Biochemical Research: Essential for academic and industrial research into protein structure-function relationships, enzyme mechanisms, and peptide mimetics.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	L-Histidine, n-[(Phenylmethoxy)Carbonyl]-1-(Triphenylmethyl)-
CAS No.	82882-71-1
Molecular Formula	C34H31N3O4
Molecular Weight	545.63 g/mol
Synonyms	Nα-Cbz-Nim-Trt-L-histidine; Nα-Carbobenzoxy-Nim-trityl-L-histidine; Z-His(Trt)-OH; Cbz-His(Trt)-OH; Nα-(Benzyloxycarbonyl)-Nim-(triphenylmethyl)-L-histidine; (2S)-2-[[(Benzyloxy)carbonyl]amino]-3-[1-[(triphenylmethyl)amino]imidazol-4-yl]propanoic acid; Fmoc-His(Trt)-OH precursor; Protected L-Histidine derivative
EINECS	Contact for details

Quality Control

Our L-Histidine, n-[(Phenylmethoxy)Carbonyl]-1-(Triphenylmethyl)- is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements, including those for cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.