Description

4-Azido-3-Iodophenylalanine is a specialized, non-natural amino acid derivative that serves as a critical building block in advanced chemical synthesis. This compound is valued for its dual functional groups, enabling its use as a versatile click chemistry reagent and a photoaffinity labeling probe. It is primarily required by researchers and manufacturers in the pharmaceutical, biotechnology, and chemical development sectors for applications in drug discovery, proteomics, and materials science.

Application

• Click Chemistry Reagent: Utilized in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for bioconjugation and polymer synthesis.
• Photoaffinity Labeling (PAL): Acts as a probe to study protein-ligand interactions and identify binding sites due to its photoreactive azido group.
• Peptide & Protein Modification: Incorporated into peptides to introduce iodine for radiolabeling or to attach fluorescent tags and other payloads.
• Chemical Biology Research: Serves as a key intermediate in the development of activity-based probes and diagnostic agents.
• Materials Science: Used in the surface functionalization of nanomaterials and the creation of smart polymeric materials.
• Pharmaceutical Intermediate: Employed in the research and development stages of novel therapeutic compounds.

Basic Information

Product Name	4-Azido-3-Iodophenylalanine
CAS No.	82810-71-7
Molecular Formula	C9H8IN3O2
Molecular Weight	317.09 g/mol
Synonyms	3-Iodo-4-azido-L-phenylalanine; L-4-Azido-3-iodophenylalanine; 4-Azido-3-iodo-L-phenylalanine; (2S)-2-Amino-3-(4-azido-3-iodophenyl)propanoic acid; PAL Probe; Azido-iodo-Phe; Click Chemistry Amino Acid; AIPA
EINECS	Contact for details

Quality Control

Our 4-Azido-3-Iodophenylalanine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure enantiomeric purity. Certificates of Analysis (COA) detailing all specifications are provided to guarantee consistency and reliability for your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic and light-sensitive nature, the material should be handled in a controlled environment and allowed to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Chiral Purity (HPLC)	≥ 98% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.