Description

Pyroglutamyl-Histidyl-Alanine is a synthetic tripeptide derivative of significant interest in biochemical and pharmaceutical research. This compound serves as a crucial building block and reference standard for studying peptide structure, function, and metabolism. It is primarily utilized by research institutions and manufacturers in the life sciences sector for applications ranging from analytical chemistry to advanced drug discovery. The consistent quality and reliable supply of this peptide are essential for ensuring reproducible experimental and production outcomes.

Application

• Biochemical Research: Used as a reference standard and substrate in enzymatic studies and metabolic pathway analysis.
• Pharmaceutical Development: Serves as a key intermediate or pharmacophore model in the design and synthesis of novel therapeutic peptides.
• Analytical Chemistry: Employed as a high-purity calibration standard for HPLC, LC-MS, and other chromatographic methods in quality control laboratories.
• Cosmeceutical Research: Investigated for potential bioactive properties in advanced skincare and dermatological formulations.
• Academic Studies: Utilized in university and institutional labs for teaching and research on peptide chemistry and biochemistry.
• Process Development: Acts as a model compound for optimizing large-scale peptide synthesis and purification processes.

Basic Information

Product Name	Pyroglutamyl-Histidyl-Alanine
CAS No.	82780-19-6
Molecular Formula	C17H23N7O6
Molecular Weight	421.41 g/mol
Synonyms	pGlu-His-Ala; Pyroglutamylhistidylalanine; 5-Oxo-L-prolyl-L-histidyl-L-alanine; L-Pyroglutamyl-L-histidyl-L-alanine; (S)-2-((S)-1-((S)-5-Oxopyrrolidine-2-carboxamido)-3-(1H-imidazol-4-yl)propanamido)propanoic acid; TRH Fragment (1-3); Thyrotropin-Releasing Hormone Fragment (1-3); pGlu-His-Ala-OH
EINECS	Contact for details

Quality Control

Our Pyroglutamyl-Histidyl-Alanine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry conditions to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.