Description

Pyroglutamyl-3-Methylhistidyl-Glycine is a synthetic tripeptide derivative, also known as a pyroglutamate-modified peptide. This compound is valued for its role as a key intermediate in advanced peptide synthesis and pharmaceutical research, offering precise structural control. It is primarily sought by research institutions and manufacturers in the pharmaceutical, cosmetic, and biotechnology sectors for developing novel therapeutic agents and bioactive ingredients.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of more complex peptide-based drugs and active pharmaceutical ingredients (APIs).
• Cosmetic & Skincare Actives: Used in R&D for formulating anti-aging, skin-repair, and moisturizing products due to its peptide structure.
• Biochemical Research: Serves as a standard or reagent in proteomics, enzymology, and cell signaling pathway studies.
• Nutraceutical Development: Investigated for potential applications in functional food and dietary supplement formulations.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	Pyroglutamyl-3-Methylhistidyl-Glycine
CAS No.	82780-18-5
Molecular Formula	C16H23N5O5
Molecular Weight	365.39 g/mol
Synonyms	L-Pyroglutamyl-L-3-methylhistidyl-glycine; pGlu-3-MeHis-Gly-OH; 5-Oxo-L-prolyl-L-3-methylhistidylglycine; (S)-2-(5-Oxopyrrolidine-2-carboxamido)-3-(1-methyl-1H-imidazol-5-yl)propanoic acid; 3-Methylhistidine-containing tripeptide; pGlu-MeHis-Gly; L-Pyroglutamyl-L-3-methylhistidylglycine; Pyroglutamate-3-methylhistidine-glycine tripeptide
EINECS	Contact for details

Quality Control

Our Pyroglutamyl-3-Methylhistidyl-Glycine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and residual solvent screening, to ensure it meets high-grade specifications suitable for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Total)	≥ 99.0%
Optical Rotation	Specific range provided per COA
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.