Description

Prourokinase is a high-purity, single-chain glycoprotein and the inactive zymogen precursor of the serine protease urokinase. This compound is of significant value in pharmaceutical research and development due to its role as a key intermediate in the production of thrombolytic agents. It is primarily needed by manufacturers in the biopharmaceutical sector for the development and production of advanced cardiovascular and fibrinolytic therapies, as well as by research institutions studying plasminogen activation and related biochemical pathways.

Application

• As a critical active pharmaceutical ingredient (API) intermediate in the manufacture of thrombolytic drugs.
• For biochemical research into the fibrinolytic system, plasminogen activation mechanisms, and vascular biology.
• In the development of in-vitro diagnostic (IVD) reagents and assay kits for hemostasis and thrombosis testing.
• As a reference standard in quality control laboratories for the analysis of urokinase-based pharmaceutical products.
• Used in studies focused on cell surface proteolysis, cancer metastasis, and tissue remodeling.

Basic Information

Product Name	Prourokinase
CAS No.	82657-92-9
Molecular Formula	C₁₉₉₆H₃₀₉₈N₅₇₂O₆₀₀S₁₆
Molecular Weight	~46,000 Da
Synonyms	Single-Chain Urokinase-Type Plasminogen Activator; sc-uPA; Pro-urokinase; Urokinase Precursor; Plasminogen Activator, Urokinase Precursor; Urinary Plasminogen Activator Single-Chain Form; EC 3.4.21.73 (precursor)
EINECS	Contact for details

Quality Control

Our Prourokinase is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity, SDS-PAGE, and bioactivity assays to ensure it meets stringent specifications for pharmaceutical research. A detailed Certificate of Analysis (COA) documenting purity, biological activity, endotoxin levels, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake. For short-term use, store at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Conforms to reference standard
Purity (SDS-PAGE)	≥ 95% (Single Chain Form)
Assay (HPLC)	≥ 98.0%
Specific Activity	≥ 100,000 IU/mg
Endotoxin	< 1.0 EU/mg
Protein Content (UV)	≥ 90%
Solubility	Soluble in water or buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.