Description

Fmoc-L-4-Iodophenylalanine CAS NO 82565-68-2 is a protected, non-natural amino acid derivative featuring an iodine atom on the aromatic ring, making it a versatile building block for peptide synthesis and medicinal chemistry. Its core value lies in the orthogonally protected amine (Fmoc) and carboxylic acid groups, which allow for precise, sequential incorporation into complex peptide chains using standard solid-phase peptide synthesis (SPPS) protocols. This compound is essential for researchers and manufacturers in pharmaceutical R&D, particularly for developing peptide-based therapeutics, diagnostic probes, and as a key intermediate in the synthesis of targeted bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A critical building block for the automated synthesis of custom peptides containing iodinated phenylalanine residues.
• Pharmaceutical Intermediate: Used in the research and development of novel peptide drugs, hormone analogs, and enzyme inhibitors.
• Radiolabeling Precursor: The iodine atom serves as a handle for radioiodination (e.g., with I-125 or I-131) to create peptides for diagnostic imaging (SPECT) or targeted radiotherapy.
• Chemical Biology & Proteomics: Incorporation into peptides for studying protein-protein interactions, receptor binding, and as a site-specific tag for bioconjugation.
• Material Science: Potential use in creating functionalized surfaces or specialty polymers with unique electronic or structural properties.
• Academic & Contract Research: A valuable reagent for synthetic organic chemistry and peptide research in university and CRO laboratories.

Basic Information

Product Name	Fmoc-L-4-Iodophenylalanine
CAS No.	82565-68-2
Molecular Formula	C24H20INO4
Molecular Weight	513.32 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-iodo-L-phenylalanine; Fmoc-4-Iodo-L-Phe-OH; Fmoc-Phe(4-I)-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-(4-iodophenyl)propanoic acid; N-Fmoc-4-iodo-L-phenylalanine; Fmoc-L-4-Iodo-Phe; N-α-Fmoc-4-iodo-L-phenylalanine
EINECS	Contact for details

Quality Control

Our Fmoc-L-4-Iodophenylalanine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and purity. For long-term storage, consider storage at 2-8°C under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.