Description

Dansyl-Phenylalanyl-Leucyl-Arginine is a synthetic, dansyl-labeled tetrapeptide substrate designed for high-sensitivity enzymatic assays. This compound matters for researchers and quality control laboratories requiring precise, fluorometric detection of specific protease activity, offering superior sensitivity over colorimetric methods. It is primarily needed by the pharmaceutical, biotechnology, and diagnostic industries for enzyme kinetics studies, inhibitor screening, and proteolytic activity profiling.

Application

• Protease Activity Assays: Fluorogenic substrate for the detection and quantification of trypsin-like serine protease activity.
• Enzyme Kinetics & Inhibitor Screening: Essential tool in pharmaceutical R&D for studying enzyme mechanisms and evaluating potential therapeutic inhibitors.
• Diagnostic Development: Used in the development of clinical diagnostic kits for conditions involving abnormal protease levels.
• Biochemical Research: A key reagent in academic and industrial research focused on proteolysis, signal transduction, and protein function.
• Quality Control in Biologics: Employed in QC testing of biopharmaceuticals to monitor and control residual protease activity during manufacturing.

Basic Information

Product Name	Dansyl-Phenylalanyl-Leucyl-Arginine
CAS No.	82543-28-0
Molecular Formula	C36H52N8O7S
Molecular Weight	740.92 g/mol
Synonyms	Dansyl-Phe-Leu-Arg; Dns-Phe-Leu-Arg; D-Phenylalanyl-L-leucyl-L-arginine 5-(dimethylamino)naphthalene-1-sulfonate; L-Arginine, N2-[N-[N-[N-[5-(dimethylamino)-1-naphthalenyl]sulfonyl]-L-phenylalanyl]-L-leucyl]-; Fluorogenic Substrate for Trypsin; 82543-28-0; Dansyl fluorophore-labeled peptide
EINECS	Contact for details

Quality Control

Our Dansyl-Phenylalanyl-Leucyl-Arginine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, critical for reliable assay performance. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and performance in standard assays. We support research and diagnostic applications requiring traceable and reproducible biochemical reagents.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (Mass Spec)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in water
Functional Activity	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.