Description

Methionine-Enkephalin, 5-Amino-Val(2)-Des-Gly(3)- is a synthetic peptide analog of the endogenous opioid peptide Met-enkephalin, modified to enhance its stability and receptor binding profile. This compound is of significant value for advanced research in neurobiology and pharmacology, particularly in the study of opioid receptor mechanisms and pain modulation pathways. It is primarily required by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on developing novel neuroactive compounds and therapeutic agents.

Application

• Neuroscience Research: Used as a critical tool for studying the function and distribution of delta (δ) and mu (μ) opioid receptors in the central nervous system.
• Pharmacological Assay Development: Serves as a reference standard or active ligand in competitive binding assays and functional cell-based tests to screen for new analgesic compounds.
• Biochemical Studies: Employed in structure-activity relationship (SAR) studies to understand the impact of specific amino acid modifications on peptide stability and biological activity.
• Drug Discovery Programs: Acts as a lead compound or intermediate in the development of peptide-based therapeutics targeting chronic pain and neurological disorders.

Basic Information

Product Name	Methionine-Enkephalin, 5-Amino-Val(2)-Des-Gly(3)-
CAS No.	82518-82-9
Molecular Formula	C27H39N5O6S
Molecular Weight	561.70 g/mol
Synonyms	5-Amino-Val(2)-Des-Gly(3)-Met-Enkephalin; [5-Aminovaleric acid(2)]Met-Enkephalin; H-Tyr-5-Ava-Phe-Met-OH; Met-Enkephalin (5-Ava(2)) analog; Opioid peptide analog 82518-82-9; 5-AVA(2)-Met-Enkephalin; Tyr-D-5-Ava-Phe-Met-OH (sequence variant); Modified Enkephalin Peptide
EINECS	Contact for details

Quality Control

Our Methionine-Enkephalin, 5-Amino-Val(2)-Des-Gly(3)- is produced under strict quality management systems suitable for research applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity and MS for identity confirmation, to ensure high consistency and reliability. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.