Description

β-Endorphin, Tyr(31) CAS NO 82284-46-6 is a synthetic peptide analog of the endogenous opioid neuropeptide β-endorphin, specifically modified at the tyrosine-31 position. This modification is critical for research into receptor binding affinity, selectivity, and metabolic stability, making it a valuable tool for neuropharmacological studies. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on pain management, neuropsychiatric disorders, and opioid receptor signaling pathways.

Application

• Neuroscience Research: Investigation of opioid receptor (MOP, DOP, KOP) binding, activation, and downstream signaling cascades.
• Pain Mechanism Studies: Used as a reference standard or active agent in models studying endogenous pain modulation and analgesia.
• Drug Discovery & Development: Serving as a lead compound or molecular probe for designing novel analgesics with improved efficacy and reduced side-effect profiles.
• Biochemical Assays: Application in competitive binding assays, ELISA development, and receptor autoradiography to quantify receptor density and ligand affinity.
• Metabolic Stability Testing: Evaluation of peptide degradation pathways and half-life in various biological matrices to inform drug design.
• Academic & Clinical Research: Fundamental studies on stress response, mood regulation, and the neurobiology of addiction.

Basic Information

Product Name	β-Endorphin, Tyr(31)
CAS No.	82284-46-6
Molecular Formula	C158H251N39O46S
Molecular Weight	3466.0 g/mol (approximately)
Synonyms	β-Endorphin (Tyr31); H-Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys-Asn-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-Gly-Glu-OH; Tyr31-β-Endorphin; β-Endorphin (31-Tyrosine); [Tyr31]β-Endorphin; Opioid Peptide (Tyr31 analog); END Tyr31
EINECS	Contact for details

Quality Control

Every batch of β-Endorphin, Tyr(31) is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency for critical research applications. Certificates of Analysis (COA) detailing purity by HPLC, amino acid analysis, and mass spectrometry are available for every lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Amino Acid Composition	Within ±10% of theoretical values
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80% (by weight)
Solubility	Soluble in water, acetic acid, or DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.