Description

Cyclo(Phenylalanyl-Prolyl)4 CAS NO 82263-43-2 is a synthetic cyclic peptide composed of repeating phenylalanine-proline dipeptide units, forming a constrained macrocyclic structure. This unique architecture offers enhanced metabolic stability and specific conformational properties, making it a valuable scaffold in advanced pharmaceutical research and development. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, particularly for targeting protein-protein interactions and developing novel therapeutic agents.

Application

• Pharmaceutical Research & Drug Discovery: Serves as a privileged scaffold for designing and screening new bioactive compounds, especially enzyme inhibitors and receptor modulators.
• Peptide-Based Therapeutic Development: Used in the development of stable peptide mimetics with improved pharmacokinetic profiles over linear peptides.
• Chemical Biology & Proteomics: Employed as a molecular tool to study biological processes, protein folding, and intermolecular recognition events.
• Material Science: Investigated for creating novel bio-inspired materials and nanostructures due to its self-assembly potential.
• Academic & Industrial R&D: A key intermediate for synthetic chemists and biologists exploring cyclic peptide chemistry and its applications.

Basic Information

Product Name	Cyclo(Phenylalanyl-Prolyl)4
CAS No.	82263-43-2
Molecular Formula	C52H56N8O8
Molecular Weight	921.06 g/mol
Synonyms	Cyclo(-Phe-Pro-)4; Cyclo(Phe-Pro)4; Cyclic(Phenylalanyl-Prolyl) Tetramer; 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid derivative (contextual); Cyclic Tetrapeptide (Phe-Pro)4; CPP4; [Cyclo(Phe-Pro)]4; FK-506 related cyclic peptide analog (research context)
EINECS	Contact for details

Quality Control

Our Cyclo(Phenylalanyl-Prolyl)4 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and nuclear magnetic resonance (NMR) for structural verification. We provide Certificates of Analysis (COA) with each shipment, detailing all relevant specifications to ensure the material meets the rigorous standards required for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.