Description

Enkephalinamide-Leu, Ala(2)-Aminoethyl Dimer is a synthetic peptide dimer derivative based on the structure of enkephalin, an endogenous opioid peptide. This compound is of significant interest for advanced research in neurobiology and pharmacology, particularly in the study of opioid receptor interactions and signal transduction pathways. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on developing novel therapeutic agents for pain management and neurological disorders.

Application

• Neuroscience Research: As a specialized tool compound for investigating the binding affinity and functional activity at delta (δ) and mu (μ) opioid receptors.
• Drug Discovery & Development: Serving as a key intermediate or reference standard in the design and synthesis of new peptide-based analgesics with potentially improved efficacy or reduced side-effect profiles.
• Biochemical Assays: Used in competitive binding assays, receptor autoradiography, and studies of G-protein coupled receptor (GPCR) activation and internalization mechanisms.
• Structure-Activity Relationship (SAR) Studies: Critical for understanding how dimerization and specific amino acid substitutions (Leu, Ala) affect peptide stability, receptor selectivity, and biological potency.
• Academic & Clinical Research: Supporting fundamental research into the endogenous opioid system, its role in pain perception, addiction, and mood regulation.

Basic Information

Product Name	Enkephalinamide-Leu, Ala(2)-Aminoethyl Dimer
CAS No.	82221-89-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	H-Tyr-Gly-Gly-Phe-Leu-NH-CH2-CH2-NH-Ala-Tyr-Gly-Gly-Phe-Leu-NH2; Leu-Enkephalinamide, Ala(2)-aminoethyl dimer; [Leu5]Enkephalin Ala(2)-aminoethyl dimer; Opioid peptide dimer; Dimeric enkephalin analog; Aminoethyl-linked enkephalin dimer; Tyr-Gly-Gly-Phe-Leu-NH-(CH2)2-NH-Ala-Tyr-Gly-Gly-Phe-Leu-NH2
EINECS	Contact for details

Quality Control

Every batch of Enkephalinamide-Leu, Ala(2)-Aminoethyl Dimer is manufactured and analyzed under strict quality management protocols to ensure identity, purity, and consistency for critical research applications. Our standard quality commitment includes comprehensive characterization by HPLC, MS, and NMR spectroscopy. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, assay, and chromatographic profile.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (HPLC)	≥ 97%
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.