Description

Glutathione Amide is a biologically active derivative of the essential tripeptide glutathione, where the terminal carboxyl group is replaced by an amide. This modification enhances its stability and cellular permeability, making it a valuable research compound and a potent precursor in biochemical synthesis. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and nutraceutical sectors for applications in redox biology, enzyme studies, and the development of advanced therapeutic agents.

Application

• Biochemical Research: Used as a key reagent and substrate in enzymatic studies related to glutathione metabolism and redox signaling pathways.
• Pharmaceutical Intermediates: Serves as a critical building block in the synthesis of novel drug candidates targeting oxidative stress and cellular detoxification.
• Cell Culture & In Vitro Studies: Employed to modulate intracellular glutathione levels and study its protective effects against oxidative damage in cell-based assays.
• Antioxidant Mechanism Studies: A vital tool for investigating the specific mechanisms of antioxidant activity and thiol-disulfide exchange reactions.
• Cosmeceutical R&D: Explored in the development of advanced skincare formulations for its potential skin-brightening and anti-aging properties.
• Diagnostic Reagent Development: Used in the formulation of assay kits and reagents for detecting glutathione-related enzyme activities.

Basic Information

Product Name	Glutathione Amide
CAS No.	82147-51-1
Molecular Formula	C10H17N4O6S
Molecular Weight	321.33 g/mol
Synonyms	L-Glutathione amide; γ-L-Glutamyl-L-cysteinylglycine amide; GSH amide; Reduced Glutathione amide; NSC 113236; Glutathionamide; (2S)-2-Amino-5-[[(2R)-1-(carbamoylmethylamino)-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acid
EINECS	Contact for details

Quality Control

Our Glutathione Amide is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and residual solvent screening, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	-15° to -20° (c=1 in H2O)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.