Description

D-His-Pro-Phe-His-Leu-Psi-(Ch2Nh)-*Leu-V Al-Tyr CAS NO 82131-82-6 is a specialized, non-hydrolyzable peptide analogue designed for advanced biochemical research and pharmaceutical development. This compound is of significant value for studying enzyme-substrate interactions, particularly as a potent and selective inhibitor for specific proteases like renin and other aspartic proteases. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in drug discovery, metabolic pathway analysis, and the development of novel therapeutic agents.

Application

• Protease Inhibition Studies: Serves as a critical tool compound for investigating the mechanism and kinetics of aspartic proteases, including renin.
• Pharmaceutical R&D: Used in high-throughput screening and lead optimization for developing new antihypertensive and cardiovascular drugs.
• Biochemical Assay Development: Acts as a reference standard or control in enzymatic assays to ensure specificity and accuracy.
• Structural Biology: Employed in X-ray crystallography and NMR studies to elucidate enzyme active site architecture and binding modes.
• Peptidomimetic Research: Provides a backbone for designing and synthesizing new peptide analogues with enhanced stability and bioactivity.

Basic Information

Item	Detail
Product Name	D-His-Pro-Phe-His-Leu-Psi-(Ch2Nh)-*Leu-V Al-Tyr
CAS No.	82131-82-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Renin Inhibitor Peptide; D-His-Pro-Phe-His-Leu-ψ[CH2NH]-Leu-Val-Ala-Tyr; H-D-His-Pro-Phe-His-Leu-ψ(CH2NH)-Leu-Val-Ala-Tyr-OH; Reduced Peptide Bond Inhibitor; Aspartic Protease Inhibitor; Statine-containing Peptide Analogue; Transition-State Mimetic Peptide
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research-grade materials. Each batch is characterized using advanced analytical techniques to confirm identity, purity, and stability. Certificates of Analysis (COA) detailing purity, HPLC chromatograms, and other critical parameters are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic nature, the container should be allowed to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Heavy Metals	< 20 ppm
Residual Solvents	Conforms to ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.